Cycloaddition reactions are highly useful tools to address 3D-rich and functionalized scaffolds. This presentation will show the successful applications of [5+2]-cycloaddition reactions to access library scaffolds containing seven-membered rings. The chemistries were validated by the University of Leeds scientists and after transfer of knowledge to our scientists at EDELRIS, up-scaling and final library syntheses were effectively performed. Hurdles, solutions and outcomes will be discussed.
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Edelris is a leading Drug Discovery CRO, providing Compound Libraries, Organic & Medicinal Chemistry, High Throughput Screening, and Analytical expert services to the Pharmaceutical, Cosmetic, Crop Protection, and Biotech sectors.
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